Gangliosides in Peripheral Nervous System during Normal Cell-Differentiation and Oncogenesis

doi:https://doi.org/10.1007/978-1-4612-5636-6_28

Book Chapter10.1007/978-1-4612-5636-6_28

Gangliosides in Peripheral Nervous System during Normal Cell-Differentiation and Oncogenesis

Firoze B. Jungalwala,K. H. Chou,Charles E. Nolan-1983-01-01-Humana Press eBooks

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TL;DRAbstract

Gangliosides have been considered to function as cell-surface markers. They have been implicated to be involved in the molecular mechanisms of several biological phenomena that occur on the cell-surface, such as contact inhibition, intracellular adhesions, immunochemical tissue specificity, hormone receptor function and internalization of various external macromolecular substances (review by Hakomori, 1981 and Yogeeswaran, 1983). Gangliosides are present in relatively high concentrations in mammalian neural tissues. Although a considerable amount of information on the composition and metabolism if gangliosides is available for the central nervous system (review by Ledeen, 1979), only a few studies have been reported on the Gangliosides of the peripheral nervous system. The major Gangliosides of the PNS generally appear to be monosialic acid-containing species, GM1 and GM3 (Svennerholm et al., 1972; Fong et al., 1976). However, Yates et al. (1976) have reported only a small amount (<10%

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Gangliosides have been considered to function as cell-surface markers. They have been implicated to be involved in the molecular mechanisms of several biological phenomena that occur on the cell-surface, such as contact inhibition, intracellular adhesions, immunochemical tissue specificity, hormone receptor function and internalization of various external macromolecular substances (review by Hakomori, 1981 and Yogeeswaran, 1983). Gangliosides are present in relatively high concentrations in mammalian neural tissues. Although a considerable amount of information on the composition and metabolism if gangliosides is available for the central nervous system (review by Ledeen, 1979), only a few studies have been reported on the Gangliosides of the peripheral nervous system. The major Gangliosides of the PNS generally appear to be monosialic acid-containing species, GM1 and GM3 (Svennerholm et al., 1972; Fong et al., 1976). However, Yates et al. (1976) have reported only a small amount (<10%

Keywords

Sialic acidGangliosidePeripheral nervous systemBiochemistryNervous systemNervous tissueInternalizationChemistry

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