Programmed self-assembly of complex DNA nanostructures

TL;DRAbstract

DNA has served as an excellent building block to self-assemble into a wide range of one-dimensional (1D), two-dimensional (2D) and three-dimensional (3D) structures with the bottom-up method. Due to the specificity of base pairing, the DNA assembly system is predictable and robust. These DNA structures with higher diversity and complexity have potential applications as templates to organize guest molecules or nanoparticles for the nanofabrication, as biosensors for the genetic diagnosis and environmental detection, and as nanocarriers to deliver and release drugs for the therapy. My major researches focus on designing a novel building block and assembly strategies to self-assemble DNA into complex nanostructures to increase the diversity and complexity. A novel building block was first constructed, which is a parallel, left-handed DNA helix containing multiple domains of half-turn-long standard B-DNA. Such a structure can be used to introduce left-handed crossings in order to increase

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