FLAIR* MRI improves diagnostic accuracy in multiple sclerosis (S29.002)

TL;DRAbstract

OBJECTIVE: To evaluate the diagnostic utility of clinical FLAIR* 3-tesla MRI in multiple sclerosis (MS). BACKGROUND: MS lesions appear to emanate from a central vein. Based on 7-tesla research MRI, it has been proposed that MRI scans with lesions suspicious for MS should be distinguishable from those with lesions caused by other neurological diseases (Tallantyre 2011). FLAIR* (Sati 2012) MRI combines FLAIR and T2* weighted scans and is obtained on a clinical MRI unit, but has not yet been studied as a tool for diagnosing MS. DESIGN/METHODS: Two experienced MS neurologists separately evaluated 87 scan pairs (FLAIR/FLAIR*), first viewing each scan alone and subsequently the two side-by-side. 68 (78[percnt]) scan pairs were from MS cases; the remaining 19 (22[percnt]) were from healthy volunteers (n=8) and other neurological diseases (n=11). To mimic the clinical scenario, raters judged whether cases represented MS based on a combination of their own experience, published criteria (Polman

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