Tissue Tropism in Intestinal Colonization

TL;DRAbstract

This chapter reviews the current understanding of the tissue tropism of bacterial pathogens, with a focus on virulent types of Escherichia coli. As surface-expressed organelles involved in bacterial attachment to the host mucosa, bacterial pili are likely to contribute to the tissue tropism of many bacterial pathogens. The enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) translocon directs the delivery of selected proteins into the internal milieu of the host cell. Loss of invasin-mediated integrin-binding activity leads to the colonization of other epithelial surfaces rich in mucus, suggesting that invasin is absolutely required for bacterial translocation into Peyer's patches. Hence, similar to intimin, invasin modulates the site of initial mucosal colonization by an enteric pathogen. Tir from EPEC and the pili of uropathogenic E. coli (UPEC) allowed the gain of significant insight into the complexity of bacterial tissue tropism and its importance for pathogenesis

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