Coherent anti-Stokes Raman scattering microscopy for pharmaceutics

TL;DRAbstract

This dissertation demonstrates coherent anti-Stokes Raman scattering (CARS) microscopy as a tool in pharmaceutical solid state development. CARS microscopy is a nonlinear optical imaging technique that uses inelastic scattering of light to provide chemically specific imaging. CARS microscopy is suitable for early stage pharmaceutical development, analyzing pure API powders as well as late stage analysis of more complex dosage forms. The strengths and weaknesses of CARS microscopy are explored in the context of pharmaceutical analysis over a wide range of samples covering a number of commonly used pharmaceutical formulation strategies. Chapter one is an introduction to the area of traditional pharmaceutical solid state analysis and provides a background to the area of CARS microscopy. Chapter two introduces and discusses hyperspectral CARS microscopy as a tool for determining pharmaceutical solid state form capable of distinguishing between hydrous and anhydrous polymorphic forms as wel

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