Day care setting ideal place for vaccination. Pediatrics (HAV).

TL;DRAbstract

Hepatitis A is highly endemic in developing countries. For example, in Sao Paulo, Brazil, 100% and 40.3% of lower and middle socioeconomic level children aged 2-11 years, respectively, have antibodies to hepatitis A. 90.4% of voluntary middle class adult blood donors are infected with the virus. Day care centers represent an important source of hepatitis A in several communities. Richtmann et al. investigated the immunogenicity and safety of the hepatitis A virus (HAV) strain GBM vaccine among 40 children attending a day care center in Sao Paulo. The children received three times 0.5 and 1.0 ml of the vaccine, the second and third dose one and six months after the first dose, respectively. All of the subjects had protective levels of antibodies in serum after two inoculations, with no serious adverse reactions observed. During the 8th month of follow-up, an outbreak of hepatitis A occurred in the day care center. Nine of the 27 control subjects developed either high titers of IgM class

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