Phospholipase A2 Regulation Of Golgi And Endosome Structure And Function

TL;DRAbstract

The transport mechanisms of secretory and endocytic pathways are responsible for the coordinated movement of proteins and lipids throughout the cell at the proper time and place. In mammalian cells, there are many proteins dedicated to maintaining organelles and the trafficking of materials between them, though the mechanisms that regulate these processes are far from being fully understood. For over a decade, the role of phospholipase and acyltransferase lipid-modifying enzymes in membrane trafficking has been described, but the identity of the proteins involved had not been determined. Inhibitor studies demonstrated that both PLA2 and LPAT enzymes regulate trafficking events and membrane tubule formation from the Golgi complex and endosomes. In the last year, one LPAT and three PLA enzymes were found to contribute to trafficking and organelle maintenance of the Golgi and endosomes, including the work described here. The function of the PLA2 enzyme complex platelet activating factor a

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