Men Undergoing ICSI: Y We Do What We Do.

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Absence of Deletion in Azoospermia (DAZ) Genes in Spermatozoa of Infertile Men with Somatic DAZ Deletions de Vries JW, Repping S, Oates R, et al. Fert Steril 2001;75:476–479 [PubMed] Men with severe oligospermia and/or nonobstructive azoospermia (NOA) require intracytoplasmic sperm injection (ICSI) and in vitro fertilization if they are going to achieve paternity. However, one of the questions that remains unanswered is whether the “genetic” defect that supposedly caused the oligospermia and/or NOA is going to be passed on to the sons of these couples. There is evidence to suggest that deletions in the Y chromosome, which are de novo occurrences, are one of the major factors responsible for this spermatogenic defect. Recent data suggest that this deletion may be passed from father to son, but there has been no information regarding the probability of this event occurring. To help determine the likelihood that such a genetic abnormality may be passed from father to son with ICS

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