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Book Chapter10.1007/978-1-59259-033-9_15

The Ret Signaling System and Its Role in Hereditary Medullary Thyroid Carcinoma

Robert F. Gagel,Gilbert J. Cote-2000-01-01-Humana Press eBooks
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TL;DRAbstract

The identification of mutations of the rearranged during transfection (c-ret) proto-oncogene causative for multiple endocrine neoplasia type 2 (MEN2) in 1993 was the first in a series of remarkable discoveries that have provided insight not only into the cause of medullary thyroid carcinoma (MTC), pheochromocytoma, and parathyroid neoplasia, but also the development of the neurologic and urogenital systems. It also illustrates one example of the frenetic and sometimes illogical process by which scientific knowledge has progressed over the past decade, mixing the use of molecular genetics, molecular biology, and animal model systems to identify and characterize a unique signaling system.

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The identification of mutations of the rearranged during transfection (c-ret) proto-oncogene causative for multiple endocrine neoplasia type 2 (MEN2) in 1993 was the first in a series of remarkable discoveries that have provided insight not only into the cause of medullary thyroid carcinoma (MTC), pheochromocytoma, and parathyroid neoplasia, but also the development of the neurologic and urogenital systems. It also illustrates one example of the frenetic and sometimes illogical process by which scientific knowledge has progressed over the past decade, mixing the use of molecular genetics, molecular biology, and animal model systems to identify and characterize a unique signaling system.

Keywords

Multiple endocrine neoplasia type 2Medullary carcinomaThyroid carcinomaPheochromocytomaMultiple endocrine neoplasiaMedullary cavityThyroidGenitourinary system

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