Evaluation of Oral Central Nervous System Depressants in Coyotes

TL;DRAbstract

Standardized gross behavioral observation test methods for evaluating the oral effectiveness of central nervous system (CNS) depressants in captive coyotes (Canis latrans) are described. The primary objective of this research was to develop a chemical for use in trap tabs that would reduce escape, struggling, and injuries to animals, particularly carnivores, captured in steel-jawed traps. The classes of chemicals that demonstrated potential for this purpose are the phenothiazines and the benzodiazepines. Of four phenothiazines evaluated, propiopromazine hydrochloride (HCl) and triflupromazine HCl showed desirable properties. Their onset of action was about 10 min, and the duration of major CNS depression lasted for about 24 h. Chlordiazepoxide HCl, a benzodiazepine, showed an onset of action in 30 to 40 min and a duration of 30 to 36 h. Testing these drugs in combination potentiated CNS depression. Propiopromazine and reserpine together produced symptoms of CNS depression that lasted f

Chat with Paper

AI Agents for this Paper