Divergent patterns of leucocyte locomotion in experimental post-traumatic osteomyelitis.

TL;DRAbstract

Leucocyte locomotion (LL) was evaluated in guinea-pigs with experimental post-traumatic osteomyelitis. Surgical procedure (fracture of the right femur), the number of micro-organisms applied to the fractured site and the time sequence of investigations were kept constant. After the right femur of guinea-pigs had been fractured, the animals were divided into three groups: in group I the fractured site remained uninfected, while in groups 2 and 3 the fractured sites were infected with either Escherichia coli (10(5] or with Staphylococcus aureus (10(4]. In a fourth group, guinea-pigs were anaesthesized only, without any further trauma. LL was significantly depressed in all three groups following trauma on postoperative day 5 as compared to pre-operative levels (P less than 0.01), but had remained normal in guinea-pigs which had been anaesthesized only. While LL returned to pre-operative levels and stayed normal in uninfected guinea-pigs and those which had been infected with E. coli, LL l

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