β-AMINO-n-VALERIC ACID

TL;DRAbstract

Only two p-aminovaleric acids appear to have been described; namely, the derivative of isovaleric acid first obtained by Heintz (1) by the oxidation of acetonamine and subsequently synthesized by Bredt (2) and by Slimmer (3) and the p-amino derivative of trimethylacetic acid prepared by Kohn and Schmidt (4).The following communication describes the preparation of p-amino-n-Valerie acid.The acid was required for purposes of comparison with a compound, precipitable by phosphotungstic acid and forming a crystalline reineckate obtained in the course of other work carried out in collaboration with the Department of Medicine of Columbia University.It may be noted here that with the exception of isoserine all P-amino acids so far available (the p-amino derivatives of propionic, n-butyric, valeric, and caproic acids, and phenylpropionic acid) have been found to yield crystalline relatively sparingly soluble reineckates, thus differentiating them sharply from the corresponding a-amino acids.The

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