Treatment of Eye Infections

TL;DRAbstract

The quinolone antimicrobials are commonly prescribed as eye drops for the therapy of anterior eye infections such as conjunctivitis and keratitis. Ophthalmic drops containing 3 mg of norfloxacin, ciprofloxacin, ofloxacin, and levofloxacin per ml (0.3% solutions) are available. Bacterial infections of the eye and contiguous tissues include conjunctivitis, keratitis, blepharitis, preseptal cellulitis, orbital cellulitis, cavernous sinus thrombosis, uveitis, and endophthalmitis. The discussion in this chapter is limited to the use and pharmacology of quinolones for the treatment of bacterial infections of the conjunctiva (conjunctivitis), cornea (keratitis), and aqueous and vitreous humors (endophthalmitis). Conjunctivitis is the most common bacterial infection of the eye and is also often caused by viruses. Although it causes local symptoms including irritation and tearing, it is rarely sight threatening and often resolves without antimicrobial therapy. Treatment of keratitis requires an

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