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Background: There are at least hundreds of potential obesity genes being documented. However, only a few dozens have been replicated more than five times in human association studies. The aim of this study was to find influential obesity candidate genes and those major ones interacting with dietary factors in Taiwanese population. Materials and methods: This study was within Cardiovascular Disease Risk Factor Two-township Study (CVDFACTS), using nested case-control study design. 285 obese subjects (BMI*≧27kg/m2) of the cohort were included (71%) and 285 overweight subjects (24kg/m2<BMI≦27kg/m2) were randomly selected (42%). We obtained 554 age-sex grouped matched normal BMI control (38%) and chose 15 SNPs in 12 genes: ADRB2 (Arg16Gly, Gln27Glu), ESR1 A+51193T, FABP2 Ala54Thr, LEP A-2548G, LEPR Gln223Arg, PLIN G+11842A, PPARD T-87C, PPARG (G-82362A, Pro12Ala, G+28752A), TNFA G-308A, TNFB G+252A, UCP2 Ala55Val, and UCP3 C-55T. They conformed to at least one of the following criteria: (1)
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Background: There are at least hundreds of potential obesity genes being documented. However, only a few dozens have been replicated more than five times in human association studies. The aim of this study was to find influential obesity candidate genes and those major ones interacting with dietary factors in Taiwanese population. Materials and methods: This study was within Cardiovascular Disease Risk Factor Two-township Study (CVDFACTS), using nested case-control study design. 285 obese subjects (BMI*≧27kg/m2) of the cohort were included (71%) and 285 overweight subjects (24kg/m2<BMI≦27kg/m2) were randomly selected (42%). We obtained 554 age-sex grouped matched normal BMI control (38%) and chose 15 SNPs in 12 genes: ADRB2 (Arg16Gly, Gln27Glu), ESR1 A+51193T, FABP2 Ala54Thr, LEP A-2548G, LEPR Gln223Arg, PLIN G+11842A, PPARD T-87C, PPARG (G-82362A, Pro12Ala, G+28752A), TNFA G-308A, TNFB G+252A, UCP2 Ala55Val, and UCP3 C-55T. They conformed to at least one of the following criteria: (1)
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