Biological oxidants and therapeutic antioxidants

TL;DRAbstract

A book chapter represents a special type of literature overview, which offers the promise of covering topics and addressing issues which are relevant and topical but which will also stand the test of time. It is appealing to focus on topical issues, which will hopefully provide some immediate insight into problems and questions confronting investigators in the field. However, undue focus on topical issues predisposes the discussion to becoming dated prior to, or shortly after, appearing in print. Thus, the expressed purpose of this chapter will be to deal with broader concepts which will, hopefully, provide stable foundations to interpret results and permit better comprehension of both current and future topical issues relating to nitrogen oxide-derived oxidative injury relevant to neurodegenerative disease. The author's training and research background is in the chemistry and biochemistry of biologically produced oxidants, biochemical mechanisms of oxidative injury, and the pharmacolo

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