交联甲壳胺-PEG-尼莫地平缓释颗粒性质及释药特性

TL;DRAbstract

Objective To investigate the property of rosslinked chitosan-PEG-nimodipine sustained release granules and its drug release characteristics in vitro. Methods The rosslinked chitosan-PEG-nimodipine sustained release granules were prepared using emulsification-crosslinking method. The structures of the granules were characterized by IR spectrometry and its shape and surface were characterized by scanning electron microscope. The distribution of particle diameter, the amount of drug in the granules and the amount of dissolution in different pH mediums were also investigated. Results Scanning electron microscopy shows that the granules were globoid and smooth, very few granules with accidented surface. The mean particle diameter of rosslinked chitosan-PEG-nimodipine granules was 1.20mm. Infrared spectrum indicated that Schiffs base was formed by the amino-group of chitosan and the carbonyl group of glutaraldehyde. Rosslinked chitosan-PEG-nimodipine granules possessed sustained release prop

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