TL;DRAbstract
It is generally accepted that high levels of plasma cholesterol represent an important risk factor for coronary artery disease. However, more resent research suggests that high serum levels of triglyceride (TG)-rich lipoproteins, i.e, very low density lipoprotein (VLDL) and its remnants are also important risk factors.1,2 Serum lipids can be lowered either by dietary treatment with fish oil or by pharmacological treatment with drugs of the fibrate class.5 Fibrate action has been partly ascribed to increased fatty acid oxidation, decreased TG synthesis and secretion, and enhanced clearance of VLDL from serum due to a down-regulation of hepatic apoC-III gene-expression.6,7 Besides lowering plasma lipids and the apparent protection in thrombosis, dietary supplements enriched in omega-3 fatty acids have proved to lower blood pressure, alter lipoprotein metabolism and dampen platelet aggregation among other beneficial effects in humans.8–10 The two components of fish oil attracting the most
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It is generally accepted that high levels of plasma cholesterol represent an important risk factor for coronary artery disease. However, more resent research suggests that high serum levels of triglyceride (TG)-rich lipoproteins, i.e, very low density lipoprotein (VLDL) and its remnants are also important risk factors.1,2 Serum lipids can be lowered either by dietary treatment with fish oil or by pharmacological treatment with drugs of the fibrate class.5 Fibrate action has been partly ascribed to increased fatty acid oxidation, decreased TG synthesis and secretion, and enhanced clearance of VLDL from serum due to a down-regulation of hepatic apoC-III gene-expression.6,7 Besides lowering plasma lipids and the apparent protection in thrombosis, dietary supplements enriched in omega-3 fatty acids have proved to lower blood pressure, alter lipoprotein metabolism and dampen platelet aggregation among other beneficial effects in humans.8–10 The two components of fish oil attracting the most
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