Development of a Cavitation Bubble Observation System and Application to Study Expansion Waves and Shock Waves

TL;DRAbstract

Minimally invasive therapies by applying cavitation bubbles, such as histotripsy and gene transfer, have recently attracted attention. As a method to generate bubbles, the use of expansion waves is expected to be more effective than using shock waves or ultrasound. However, few studies have confirmed the effectiveness of expansion waves in generating bubbles. Previous studies have investigated this issue using biological targets. When contrast agents were injected prior to exposure to expansion waves, a larger hemorrhage was observed after the exposure. However, without contrast agents, little difference in hemorrhage was observed. Thus, at least with biological targets, it is still uncertain whether cavitation bubbles are generated more effectively by expansion waves or by shock waves. In this study, we developed a novel cavitation bubble observation system, and used it to observe bubble dynamics created by either expansion waves or shock waves. A spherical wave generated by electric

Chat with Paper

AI Agents for this Paper