Issues in the genetic study of complex neurobehavioral conditions

TL;DRAbstract

This chapter discusses some of the issues that need to be considered in the genetic study of complex phenotypes. First critical issue in any genetic study is the accurate delineation of the inherited phenotype. The issue of phenotypic classification is particularly critical in genetic linkage studies. Second critical issue in the search for genes important for the manifestation of behavior is the assessment of the phenotype. Neuroimaging data could be very helpful in elucidating more quantitative biological aspects of the phenotype. A third issue has to do with methodologic approaches. Until recently, there has been an almost exclusive commitment to one approach. A fourth issue in the study of the genetics of behavior is the relative lack of attention to nongenetic risk factors. The final and fifth issue is the lack of a developmental focus in genetic studies of neurobehavior.

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