Development of Opioid Transdermal Delivery Systems

TL;DRAbstract

Opioid therapies have been and will continue to be a vital part of opioid addiction and alcoholism treatments, as well as a vital part of chronic and acute pain management regimens. Transdermal delivery of opioid antagonists and ago nists can be advantageous in order to help improve the quality of life of many patients. This mode of drug administration offers many advantages when compared to the traditional oral route of drug delivery, including avoidance of hepatic first-pass metabolism, the potential for long-term controlled release with smoothing of the typical peak-trough plasma drug concentration profiles associated with multi ple dosing regimens, the ease of administration, and the possibility of immediate withdrawal of the treatment. Although the majority of the opioids used in clinical practice do not have ideal physicochemical properties that would allow them to reach therapeutic plasma levels by passive skin permeation, many advances have been made in the transdermal delivery

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