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George Thomas

Oregon Health & Science University(US)

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212

Papers

32.7K

Citations

94

h-index

158

i10-index

George Thomas is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: PI3K/AKT/mTOR signaling in cancer & Protein Kinase Regulation and GTPase Signaling & RNA and protein synthesis mechanisms. The author has an h-index of 94, co-authored 181 publications.

ORCID: 0000-0003-3518-8149

Research Topics

PI3K/AKT/mTOR signaling in cancer Protein Kinase Regulation and GTPase Signaling RNA and protein synthesis mechanisms Metabolism, Diabetes, and Cancer Ubiquitin and proteasome pathways

Papers by this author

works

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

2010 · Cell Metabolism · 854 citations

https://doi.org/10.1016/j.cmet.2010.03.014

Adem Kalender Anand Selvaraj So Young Kim Pawan Gulati

<i>S6K1</i> <sup>−/−</sup> / <i>S6K2</i> <sup>−/−</sup> Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

2004 · Molecular and Cellular Biology · 731 citations

https://doi.org/10.1128/mcb.24.8.3112-3124.2004

Mario Pende Sung Hee Um Virginie Mieulet Melanie Sticker

5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint

2013 · Cell Reports · 254 citations

https://doi.org/10.1016/j.celrep.2013.05.045

Giulio Donati Suresh Peddigari Carol A. Mercer George Thomas

S6K1 Phosphorylates and Regulates Fragile X Mental Retardation Protein (FMRP) with the Neuronal Protein Synthesis-dependent Mammalian Target of Rapamycin (mTOR) Signaling Cascade

2008 · Journal of Biological Chemistry · 214 citations

https://doi.org/10.1074/jbc.c800055200

Usha Narayanan Vijayalaxmi Nalavadi M. Nakamoto George Thomas

Regulation of an Activated S6 Kinase 1 Variant Reveals a Novel Mammalian Target of Rapamycin Phosphorylation Site

2002 · Journal of Biological Chemistry · 179 citations

https://doi.org/10.1074/jbc.m201745200

Masao Saitoh Nick Pullen Paul Brennan Doreen A. Cantrell

A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies

2017 · Targeted Oncology · 112 citations

https://doi.org/10.1007/s11523-017-0482-9

Trisha M. Wise‐Draper Ganesh Moorthy Mohamad A. Salkeni Nagla Abdel Karim

Research topics

topics

PI3K/AKT/mTOR signaling in cancer

Protein Kinase Regulation and GTPase Signaling

RNA and protein synthesis mechanisms

Metabolism, Diabetes, and Cancer

Ubiquitin and proteasome pathways

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