Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
2019 · Journal of the American Chemical Society · 326 citations
https://doi.org/10.1021/jacs.9b02822
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James M. Bennett
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James M. Bennett is an academic researcher from Nuffield Orthopaedic Centre. The author has contributed to research in topics: Crystallization and Solubility Studies & X-ray Diffraction in Crystallography & Protein Degradation and Inhibitors. The author has an h-index of 36, co-authored 142 publications.
ORCID: 0000-0003-1396-8400Papers by this author
worksFragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
2021 · Science Advances · 202 citations
https://doi.org/10.1126/sciadv.abf8711
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors
2023 · Science · 163 citations
https://doi.org/10.1126/science.abo7201
Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells
2003 · Biochemical Journal · 115 citations
https://doi.org/10.1042/bj20030318
Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography
2025 · Angewandte Chemie International Edition · 7 citations
https://doi.org/10.1002/anie.202424373
Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases
2024 · European Journal of Medicinal Chemistry · 4 citations
https://doi.org/10.1016/j.ejmech.2024.116292
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