The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 · Science · 14K citations
https://doi.org/10.1126/science.1072994
D
Dennis J. Selkoe
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Dennis J. Selkoe is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Alzheimer's disease research and treatments & Cholinesterase and Neurodegenerative Diseases & Prion Diseases and Protein Misfolding. The author has an h-index of 171, co-authored 573 publications.
ORCID: 0000-0001-8846-9767Papers by this author
worksThe amyloid hypothesis of Alzheimer's disease at 25 years
2016 · EMBO Molecular Medicine · 5,853 citations
https://doi.org/10.15252/emmm.201606210
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 · Nature Reviews Molecular Cell Biology · 4,653 citations
https://doi.org/10.1038/nrm2101
Alzheimer's Disease Is a Synaptic Failure
2002 · Science · 4,346 citations
https://doi.org/10.1126/science.1074069
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
2008 · Nature Medicine · 3,585 citations
https://doi.org/10.1038/nm1782
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 · Science · 3,251 citations
https://doi.org/10.1126/science.aad8373
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