Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors
2012 · Journal of Biological Chemistry · 176 citations
https://doi.org/10.1074/jbc.m112.354373
J
James R. Fuchs
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James R. Fuchs is an academic researcher from American Association of Colleges of Pharmacy. The author has contributed to research in topics: HIV/AIDS drug development and treatment & HIV Research and Treatment & Signaling Pathways in Disease. The author has an h-index of 49, co-authored 170 publications.
ORCID: 0000-0002-8743-6389Papers by this author
worksA novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
2010 · Molecular Cancer · 148 citations
https://doi.org/10.1186/1476-4598-9-217
The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity
2010 · Molecular Cancer · 115 citations
https://doi.org/10.1186/1476-4598-9-165
New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells
2009 · BMC Cancer · 87 citations
https://doi.org/10.1186/1471-2407-9-99
PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer
2022 · Cell Death and Disease · 31 citations
https://doi.org/10.1038/s41419-021-04495-w
A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase
2014 · Journal of Biological Chemistry · 30 citations
https://doi.org/10.1074/jbc.m114.589572
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