Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
2020 · Nature Communications · 154 citations
https://doi.org/10.1038/s41467-020-16564-3
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Anass Chiki
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Anass Chiki is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Genetic Neurodegenerative Diseases & Mitochondrial Function and Pathology & Parkinson's Disease Mechanisms and Treatments. The author has an h-index of 19, co-authored 40 publications.
ORCID: 0000-0002-5675-9644Papers by this author
worksN-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
2018 · Journal of Biological Chemistry · 89 citations
https://doi.org/10.1074/jbc.ra118.004621
Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology
2019 · Neurobiology of Aging · 76 citations
https://doi.org/10.1016/j.neurobiolaging.2019.08.007
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
2020 · Journal of Biological Chemistry · 57 citations
https://doi.org/10.1074/jbc.ra119.012517
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
2021 · Scientific Reports · 34 citations
https://doi.org/10.1038/s41598-021-97334-z
The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1
2021 · Journal of Molecular Biology · 33 citations
https://doi.org/10.1016/j.jmb.2021.167222
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