Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism
2006 · Science · 584 citations
https://doi.org/10.1126/science.1131542
T
Thomas Eicher
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Thomas Eicher is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Antibiotic Resistance in Bacteria & Drug Transport and Resistance Mechanisms & German Literature and Culture Studies. The author has an h-index of 8, co-authored 21 publications.
Papers by this author
worksTransport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
2012 · Proceedings of the National Academy of Sciences · 339 citations
https://doi.org/10.1073/pnas.1114944109
Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB
2008 · Nature Structural & Molecular Biology · 151 citations
https://doi.org/10.1038/nsmb.1379
Structural and functional aspects of the multidrug efflux pump AcrB
2009 · Biological Chemistry · 58 citations
https://doi.org/10.1515/bc.2009.090
Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS
2011 · Biochimica et Biophysica Acta (BBA) - Biomembranes · 21 citations
https://doi.org/10.1016/j.bbamem.2011.05.009
Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity
2025 · Nature Communications · 1 citations
https://doi.org/10.1038/s41467-025-66751-3
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