Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis
2019 · Nature Medicine · 834 citations
https://doi.org/10.1038/s41591-019-0512-5
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Robert Wirka
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Robert Wirka is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Atherosclerosis and Cardiovascular Diseases & Single-cell and spatial transcriptomics & Nuclear Receptors and Signaling. The author has an h-index of 20, co-authored 54 publications.
ORCID: 0000-0001-9131-9508Papers by this author
worksCoronary Disease-Associated Gene <i>TCF21</i> Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway
2019 · Circulation Research · 99 citations
https://doi.org/10.1161/circresaha.119.315968
Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk
2018 · PLoS Genetics · 61 citations
https://doi.org/10.1371/journal.pgen.1007681
TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression
2019 · Genome Medicine · 59 citations
https://doi.org/10.1186/s13073-019-0635-9
Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping
2020 · Genome biology · 31 citations
https://doi.org/10.1186/s13059-020-02049-5
Atheroma transcriptomics identifies ARNTL as a smooth muscle cell regulator and with clinical and genetic data improves risk stratification
2024 · European Heart Journal · 16 citations
https://doi.org/10.1093/eurheartj/ehae768
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