A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
2017 · Proceedings of the National Academy of Sciences · 289 citations
https://doi.org/10.1073/pnas.1610586114
M
Michele Perni
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Michele Perni is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Alzheimer's disease research and treatments & Genetics, Aging, and Longevity in Model Organisms & Parkinson's Disease Mechanisms and Treatments. The author has an h-index of 22, co-authored 46 publications.
ORCID: 0000-0001-7593-8376Papers by this author
worksSystematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
2016 · Proceedings of the National Academy of Sciences · 221 citations
https://doi.org/10.1073/pnas.1615613114
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
2020 · Science Advances · 173 citations
https://doi.org/10.1126/sciadv.abb5924
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
2020 · Communications Biology · 63 citations
https://doi.org/10.1038/s42003-020-01140-8
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease
2020 · Scientific Reports · 24 citations
https://doi.org/10.1038/s41598-020-69626-3
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles
2017 · Scientific Reports · 21 citations
https://doi.org/10.1038/s41598-017-13755-9
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