A dominant-negative effect drives selection of <i>TP53</i> missense mutations in myeloid malignancies
2019 · Science · 417 citations
https://doi.org/10.1126/science.aax3649
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Steffen Boettcher
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Steffen Boettcher is an academic researcher from University of Zurich. The author has contributed to research in topics: Acute Myeloid Leukemia Research & Hematopoietic Stem Cell Transplantation & Protein Degradation and Inhibitors. The author has an h-index of 27, co-authored 94 publications.
ORCID: 0000-0001-9937-0957Papers by this author
worksDistinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome
2021 · Nature Communications · 168 citations
https://doi.org/10.1038/s41467-021-21588-4
Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
2023 · Blood Cancer Journal · 52 citations
https://doi.org/10.1038/s41408-023-00826-6
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy
2023 · Blood · 38 citations
https://doi.org/10.1182/blood.2023020331
Clonal dynamics after allogeneic haematopoietic cell transplantation
2024 · Nature · 33 citations
https://doi.org/10.1038/s41586-024-08128-y
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
2023 · Blood Cancer Journal · 29 citations
https://doi.org/10.1038/s41408-023-00830-w
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