mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H <sup>+</sup> -ATPase
2011 · Science · 1,582 citations
https://doi.org/10.1126/science.1207056
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Alejo Efeyan
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Alejo Efeyan is an academic researcher from Spanish National Cancer Research Centre. The author has contributed to research in topics: PI3K/AKT/mTOR signaling in cancer & Cancer-related Molecular Pathways & Pancreatic function and diabetes. The author has an h-index of 32, co-authored 77 publications.
ORCID: 0000-0002-3806-6799Papers by this author
worksThe mTOR–Autophagy Axis and the Control of Metabolism
2021 · Frontiers in Cell and Developmental Biology · 306 citations
https://doi.org/10.3389/fcell.2021.655731
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses
2025 · Nature · 46 citations
https://doi.org/10.1038/s41586-025-08629-4
A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan
2024 · Nature Aging · 33 citations
https://doi.org/10.1038/s43587-024-00635-x
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
2021 · Nature Communications · 26 citations
https://doi.org/10.1038/s41467-021-23857-8
Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs
2021 · Cell Reports · 21 citations
https://doi.org/10.1016/j.celrep.2021.109372
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