Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
2018 · Nature · 1,734 citations
https://doi.org/10.1038/nature25986
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Benedikt M. Kessler
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Benedikt M. Kessler is an academic researcher from University of Oxford. The author has contributed to research in topics: Ubiquitin and proteasome pathways & Peptidase Inhibition and Analysis & Cancer, Hypoxia, and Metabolism. The author has an h-index of 102, co-authored 741 publications.
ORCID: 0000-0002-8160-2446Papers by this author
worksVariant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation
2014 · Cell · 742 citations
https://doi.org/10.1016/j.cell.2014.05.004
Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
2016 · Science · 324 citations
https://doi.org/10.1126/science.aag1465
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation
2019 · Cell Reports · 248 citations
https://doi.org/10.1016/j.celrep.2019.06.018
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair
2016 · Molecular Cell · 246 citations
https://doi.org/10.1016/j.molcel.2016.09.032
Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
2013 · Cell Reports · 153 citations
https://doi.org/10.1016/j.celrep.2013.02.013
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