Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 · Nature · 7,000 citations
https://doi.org/10.1038/nature07935
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Johan H. van Es
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Johan H. van Es is an academic researcher from Royal Netherlands Academy of Arts and Sciences. The author has contributed to research in topics: Cancer Cells and Metastasis & Wnt/β-catenin signaling in development and cancer & Digestive system and related health. The author has an h-index of 77, co-authored 168 publications.
ORCID: 0000-0002-1338-7078Papers by this author
worksIdentification of stem cells in small intestine and colon by marker gene Lgr5
2007 · Nature · 5,629 citations
https://doi.org/10.1038/nature06196
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
2011 · Gastroenterology · 3,707 citations
https://doi.org/10.1053/j.gastro.2011.07.050
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
2010 · Nature · 2,426 citations
https://doi.org/10.1038/nature09637
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
2005 · Nature · 1,507 citations
https://doi.org/10.1038/nature03659
Lineage Tracing Reveals Lgr5 <sup>+</sup> Stem Cell Activity in Mouse Intestinal Adenomas
2012 · Science · 1,055 citations
https://doi.org/10.1126/science.1224676
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