Search-and-replace genome editing without double-strand breaks or donor DNA
2019 · Nature · 4,386 citations
https://doi.org/10.1038/s41586-019-1711-4
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Alexander A. Sousa
Broad Institute(US)
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Alexander A. Sousa is an academic researcher from Broad Institute. The author has contributed to research in topics: CRISPR and Genetic Engineering & Advanced biosensing and bioanalysis techniques & RNA and protein synthesis mechanisms. The author has an h-index of 13, co-authored 17 publications.
ORCID: 0000-0001-8533-391XPapers by this author
worksEnhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 · Nature · 1,193 citations
https://doi.org/10.1038/nature24268
Designing and executing prime editing experiments in mammalian cells
2022 · Nature Protocols · 146 citations
https://doi.org/10.1038/s41596-022-00724-4
Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice
2023 · Nature Biomedical Engineering · 127 citations
https://doi.org/10.1038/s41551-023-01026-0
Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells
2024 · Nature Biomedical Engineering · 45 citations
https://doi.org/10.1038/s41551-024-01233-3
In vivo prime editing rescues alternating hemiplegia of childhood in mice
2025 · Cell · 22 citations
https://doi.org/10.1016/j.cell.2025.06.038
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