MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
2014 · Nature · 525 citations
https://doi.org/10.1038/nature13181
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Ann‐Sofie Jemth
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Ann‐Sofie Jemth is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: DNA Repair Mechanisms & Biochemical and Molecular Research & Cancer, Hypoxia, and Metabolism. The author has an h-index of 28, co-authored 93 publications.
ORCID: 0000-0002-7550-1833Papers by this author
worksStereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
2014 · Nature · 387 citations
https://doi.org/10.1038/nature13194
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
2020 · Viruses · 39 citations
https://doi.org/10.3390/v12121423
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
2020 · Journal of Biological Chemistry · 22 citations
https://doi.org/10.1074/jbc.ra120.012636
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
2021 · Cell chemical biology · 22 citations
https://doi.org/10.1016/j.chembiol.2021.06.001
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target
2020 · Journal of Biological Chemistry · 19 citations
https://doi.org/10.1074/jbc.ra120.013695
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