Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells
2006 · Cancer Biology & Therapy · 184 citations
https://doi.org/10.4161/cbt.5.6.2708
E
Eric Shi
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19
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600
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8
h-index
8
i10-index
Eric Shi is an academic researcher from Incyte (United States). The author has contributed to research in topics: Peptidase Inhibition and Analysis & HER2/EGFR in Cancer Research & Monoclonal and Polyclonal Antibodies Research. The author has an h-index of 8, co-authored 17 publications.
Papers by this author
worksDesign and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosis
2007 · Bioorganic & Medicinal Chemistry Letters · 8 citations
https://doi.org/10.1016/j.bmcl.2007.10.108
Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety
2009 · Bioorganic & Medicinal Chemistry Letters · 6 citations
https://doi.org/10.1016/j.bmcl.2009.07.052
Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition
2009 · Bioorganic & Medicinal Chemistry Letters · 4 citations
https://doi.org/10.1016/j.bmcl.2009.04.143
Corrigendum to “Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition” [Bioorg. Med. Chem. Lett. 19 (2009) 3525]
2009 · Bioorganic & Medicinal Chemistry Letters · 1 citations
https://doi.org/10.1016/j.bmcl.2009.08.015
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