Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in <i>BRCA</i> Carrier Ovarian Cancer Correlating With Platinum-Free Interval
2010 · Journal of Clinical Oncology · 984 citations
https://doi.org/10.1200/jco.2009.26.9589
J
Jan H.M. Schellens
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Jan H.M. Schellens is an academic researcher from University of Applied Sciences Utrecht. The author has contributed to research in topics: Colorectal Cancer Treatments and Studies & Cancer Treatment and Pharmacology & Cancer therapeutics and mechanisms. The author has an h-index of 111, co-authored 1009 publications.
ORCID: 0000-0001-6832-1976Papers by this author
worksDabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial
2023 · Nature Medicine · 268 citations
https://doi.org/10.1038/s41591-023-02321-8
Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in<i>in vitro</i>and<i>in vivo</i>pharmacokinetic studies employing Bcrp1−/−/Mdr1a/1b−/− (triple-knockout) and wild-type mice
2008 · Molecular Cancer Therapeutics · 199 citations
https://doi.org/10.1158/1535-7163.mct-07-2250
Evidence for Two Interacting Ligand Binding Sites in Human Multidrug Resistance Protein 2 (ATP Binding Cassette C2)
2003 · Journal of Biological Chemistry · 198 citations
https://doi.org/10.1074/jbc.m303504200
Phase I Dose-Escalation Study of the Pan-HER Inhibitor, PF299804, in Patients with Advanced Malignant Solid Tumors
2011 · Clinical Cancer Research · 180 citations
https://doi.org/10.1158/1078-0432.ccr-10-1220
Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo: Studies Using Mrp2 (Abcc2) Knockout Mice
2006 · Journal of Pharmacology and Experimental Therapeutics · 155 citations
https://doi.org/10.1124/jpet.106.101774
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