Optimierung der prophylaktischen Wirkung von Phospholipiden auf die Adhäsion von freien Kolonkarzinomzellen

TL;DRAbstract

A secondary peritoneal carcinosis based for instance on colorectal cancer, is a serious diagnosis with very poor prognosis. Therapeutic options are limited, and even radical operations are mostly not curative but palliative by nature. Therefore, the goal in every treatment of a cancer in the peritoneal cavity should be the prevention of a sowing of free cancer cells or to stop their growing. Every cancer cell needs adhesion for growing. A prevention of adhesion would prevent the surface of the peritoneal cavity form metastatic settlement. This is necessary even at early cancer states because free cancer cells are found in any staging of colorectal cancers. Many groups could demonstrate the efficacy of phospholipids in preventing adhesion of intraperitoneal structures. Therefore, it seemed to be meaningful to use phospholipids for prophylaxis of peritoneal carcinosis because mechanisms of adherence of tumor cells and peritoneal epithelial cells are similar. We could demonstrate the prot

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