Perioperative changes of ventricular function and three indicators of myocardial injury during orthotopic liver transplantation

TL;DRAbstract

Patients undergoing orthotopic liver transplantation may develop significant haemodynamic instability, especially during anhepatic phase and immediately after reperfusion of the graft. The haemodynamic instability may be caused directly by myocardial depression due to pathogenic substances released from the liver, or by acute blood loss.1 Creatine kinase(CK) and its MB fraction (CK-MB) are sensitive and specific indicators to reflect myocardial damage.2 Cardiac troponin I (cTnI) is a specific and sensitive marker of myocardial necrosis.3 This study assessed perioperative cardiac function using three indicators (CK,CK-MB,and CTnI) to evaluate perioperative myocardial damage. METHODS Patients Twenty endstage cirrhotic patients (17 men and 3 women) with cardiac function II to III and ASA III to IV were selected to undergo modified piggyback liver transplantation.4 Among them, 9 suffered from hepatitis B cirrhosis, 10 from cirrhotic hepatitis accompanied by small liver cancer, and 1 from p

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