Abstract 5065: Statins Modulate the Expression of Kruppel-Like Factor 2 in T Lymphocytes and Inhibit T Cell Responses

TL;DRAbstract

Kruppel-Like Factor 2 (KLF2) is a zinc -finger transcription factor, essential for maintenance of T cell quiescence and migration. Statins upregulate KLF2 expression in endothelial cells, but direct effects of statins on T cells are not characterized. We hypothesized that immunomodu-latory effects of statins are related partially to their influence on T cell KLF2 expression. Therefore, we characterized KLF2 expression pattern during different phases of T cell activation, examined the effects of Statins on KLF2 expression in T cells, and determined if Statins modulated pathologic T cell responses in a KLF2-dependent manner. Quantitative RT-PCR analyses indicated that KLF2 expression is relatively high in naïve mouse CD4+ and CD8+ T cells, but drops rapidly after TCR and CD28 co-stimulation and increases again as effector T cell are rested for several days. Interestingly, we also found that KLF2 is upregulated in CD8+ T cells that are functionally suppressed by FOXP3+ regulatory T cells

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