Kernmagnetische Resonanz miniaturisiert : Hyperpolarisation, niedrige Magnetfelder und Mikrostrukturen

TL;DRAbstract

This dissertation investigates three different concepts of miniaturizing nuclear magnetic resonance (NMR). The first part demonstrates the use of hyperpolarized xenon and high resolution low-field NMR devices to probe the nanostructured network of hydrogels, which show potential as drug delivery systems. It was possible to show that a certain point exists to which hydrogels can be charged to ensure that solvent is confined inside the porous structure. Upon injection of these charged drug delivery systems into organisms, it is likely that less drug molecules are lost on the way to their designated target. Moreover, it was possible to study swelling processes of hydrogels in real-time by constantly supplying hyperpolarized xenon gas. The second part focuses on the potential application of NMR for trace analysis by hyperpolarizing substrates with para-hydrogen. In specific, by using the Signal Amplification by Reversible Exchange mechanism (SABRE). Different N-heterocyclic carbene complex

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