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Article10.1161/circ.124.suppl_21.a9110

Abstract 9110: Does Change in Cardiometabolic Risk Factors Relate to Change in Coronary Artery Calcification? Findings from the Multi-Ethnic Study of Atherosclerosis (MESA)

William Argüelles,María M. Llabre,Frank J. Penedo,Martha L. Daviglus,Ralph L. Sacco,Kiang Liu+5 more-2011-11-22-Circulation
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TL;DRAbstract

How CVD risk factors impact coronary artery calcification (CAC) remains unclear. Particularly lacking are data describing how change in various risk factor levels relate to change in CAC, which may lead to a greater understanding of these relationships and further inform optimal strategies for CVD prevention and treatment. With data from a multi-ethnic cohort of 4,560 individuals (46.8% men; age M = 61.35) initially free of clinical CVD, this study used latent growth modeling to examine change in specific cardiometabolic risk factors (CRFs; waist circumference, BMI, SBP, DBP, HDL and LDL cholesterol, triglycerides, and fasting glucose) related to change in CAC over an average 4.9 year time period. Data were adjusted for baseline CRF and CAC values, age, race/ethnicity, smoking, family history of CVD, income, and use of antihypertensive, lipid-lowering, and glucose-lowering medications. Men and women were analyzed separately given previously noted differences in clinical CVD development

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How CVD risk factors impact coronary artery calcification (CAC) remains unclear. Particularly lacking are data describing how change in various risk factor levels relate to change in CAC, which may lead to a greater understanding of these relationships and further inform optimal strategies for CVD prevention and treatment. With data from a multi-ethnic cohort of 4,560 individuals (46.8% men; age M = 61.35) initially free of clinical CVD, this study used latent growth modeling to examine change in specific cardiometabolic risk factors (CRFs; waist circumference, BMI, SBP, DBP, HDL and LDL cholesterol, triglycerides, and fasting glucose) related to change in CAC over an average 4.9 year time period. Data were adjusted for baseline CRF and CAC values, age, race/ethnicity, smoking, family history of CVD, income, and use of antihypertensive, lipid-lowering, and glucose-lowering medications. Men and women were analyzed separately given previously noted differences in clinical CVD development

Keywords

MedicineCoronary artery calciumInternal medicineEthnic groupCalcificationCardiologyMesaRisk factor

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