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Article10.1161/circ.124.suppl_21.a17738

Abstract 17738: CRP Predicting Locus at 6q22 Modulates Risk of Ventricular Fibrillation in Acute Myocardial Infarction

Raha Pazoki,Michael W.T. Tanck,Darshan Dalal,Jonas S de Jong,Arthur A.M. Wilde,Connie R. Bezzina-2011-11-22-Circulation
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TL;DRAbstract

Sudden cardiac death is a leading mode of death in adults in the Western world and is largely caused by ventricular fibrillation (VF) during acute myocardial ischemia-infarction (MI). A genetic component in risk of VF in the setting of MI is recognized. However, the underlying genetic factors remain largely unknown. Plasma concentration of C-reactive protein (CRP) is a predictor of sudden cardiac death. Recently, several single nucleotide polymorphisms (SNPs) have been revealed to be associated with CRP levels in genome-wide association studies (GWAS). In this study we investigated the effect of CRP-predicting SNPs in modulation of risk of VF in acute MI. Methods: Patients studied were from the Arrhythmia Genetics in the NEtherlands Study (AGNES), consisting of patients with a first acute MI, with those suffering VF classified as cases (n=515) and those not suffering VF classified as controls (n=457). Twenty independent SNPs (r2<0.75) previously found to be associated with CRP level

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Sudden cardiac death is a leading mode of death in adults in the Western world and is largely caused by ventricular fibrillation (VF) during acute myocardial ischemia-infarction (MI). A genetic component in risk of VF in the setting of MI is recognized. However, the underlying genetic factors remain largely unknown. Plasma concentration of C-reactive protein (CRP) is a predictor of sudden cardiac death. Recently, several single nucleotide polymorphisms (SNPs) have been revealed to be associated with CRP levels in genome-wide association studies (GWAS). In this study we investigated the effect of CRP-predicting SNPs in modulation of risk of VF in acute MI. Methods: Patients studied were from the Arrhythmia Genetics in the NEtherlands Study (AGNES), consisting of patients with a first acute MI, with those suffering VF classified as cases (n=515) and those not suffering VF classified as controls (n=457). Twenty independent SNPs (r2<0.75) previously found to be associated with CRP level

Keywords

MedicineCardiologyMyocardial infarctionInternal medicineVentricular fibrillationFibrillationAtrial fibrillation

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