A case of chronic urticaria exacerbating with menstrual cycles

TL;DRAbstract

Altered function of the neuro-endocrine- immune system due to stress and other factors has been concerned in the pathogenesis of chronic urticaria. Urticaria may be associated with some diseases and conditions characterized by hormonal changes, including endocrinopathy, menstrual cycle, pregnancy, menopause and hormonal contraceptives or hormone replacement therapy. Chronic urticaria is approximately twice more frequent in women than in men. Hypersensitivity reactions to endogenous or exogenous female sex hormones have been implicated in the pathogenesis of urticarial lesions. Progesterone or estrogen-depended urticaria should be suspected in women showing eruption in cyclic interval with each menses or chronic urticarial lesions with periodic variations at different times. Here we would like to present a case of 36-year-old woman that decribes and has urticarial lesions exacerbating in menstrual periods for 12 years and remind this issue which may not take into consideration in daily

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