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Regulating NOTCH ligands: The role of Mind bomb1 during cardiac development and disease

Luxán García,Guillermo de-2013-10-18-Dialnet (Universidad de la Rioja)
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TL;DRAbstract

Resumen: Heart development is the result of the tightly regulated spatio-temporally embryonic processes of lineage specification, tissue patterning, cellular proliferation, differentiation and morphogenesis that ultimately lead to the adult, fully functional heart. Congenital heart disease (CHD) occurs when normal cardiac development is impaired and the structure of the heart and great vessels is abnormal. It is very frequent and approximately nine people in 1000 are born with a congenital heart defect. A great research effort is under way to understand the molecular and genetic bases of CHD, as they can be manifested in the neonate but also in the adult individual. In this work, we have used a conditional loss-of- function model of the Notch regulator Mib1, to show that Notch acting from the endocardium not only regulates early heart development, as it has been described previously, but also plays a crucial later role in the maturation of the cardiac valves and chambers. In the OFT va

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Resumen: Heart development is the result of the tightly regulated spatio-temporally embryonic processes of lineage specification, tissue patterning, cellular proliferation, differentiation and morphogenesis that ultimately lead to the adult, fully functional heart. Congenital heart disease (CHD) occurs when normal cardiac development is impaired and the structure of the heart and great vessels is abnormal. It is very frequent and approximately nine people in 1000 are born with a congenital heart defect. A great research effort is under way to understand the molecular and genetic bases of CHD, as they can be manifested in the neonate but also in the adult individual. In this work, we have used a conditional loss-of- function model of the Notch regulator Mib1, to show that Notch acting from the endocardium not only regulates early heart development, as it has been described previously, but also plays a crucial later role in the maturation of the cardiac valves and chambers. In the OFT va

Keywords

EndocardiumNotch signaling pathwayHeart developmentMorphogenesisMesenchymeBiologyCell biologyAnatomy

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