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Open AccessArticle10.2183/pjab1945.32.774

On the Hydroxylation of Anthranilic Acid and Kynurenine

Yahito KOTAKE,Yukio Shibata,Akio TORATANI-1956-01-01-Proceedings of the Japan Academy
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TL;DRAbstract

Both anthranilic acid and kynurenine were first successfully discovered by Yashiro Kotake et a1.,1' as the intermediate metabolites of tryptophan in the animal. It was further found out by Yashiro Kotake2' and Beadle3' that both of these substances can be hydroxylated in vivo into 5-OH-anthranilic acid and 3-OH-kynurenine respectively. But the definite mechanism of such hydroxylation remained unknown.

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Both anthranilic acid and kynurenine were first successfully discovered by Yashiro Kotake et a1.,1' as the intermediate metabolites of tryptophan in the animal. It was further found out by Yashiro Kotake2' and Beadle3' that both of these substances can be hydroxylated in vivo into 5-OH-anthranilic acid and 3-OH-kynurenine respectively. But the definite mechanism of such hydroxylation remained unknown.

Keywords

Anthranilic acidHydroxylationKynurenineChemistryBiochemistryTryptophanAmino acidEnzyme

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