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Article10.1212/wnl.84.14_supplement.p1.221

Confirmation of Grey Matter Disease Distributions in a Colombian Cohort of Patients with Frontotemporal Degeneration (P1.221)

Pablo Reyes,Diana Matallana,Luís Felipe Uriza,Carlos Cano,Murray Grossman,Corey T. McMillan+1 more-2015-04-06-Neurology
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TL;DRAbstract

OBJECTIVE: To validate the neuroanatomical distribution of disease in clinical syndromes associated with frontotemporal degeneration (FTD) in Colombia. BACKGROUND: FTD is a clinically heterogeneous disorder that includes a behavioral variant (bvFTD) and two variants of primary progressive aphasia (PPA) characterized by non-fluent agrammatic speech (naPPA) and semantic deficits (svPPA). It is well established that each clinical syndrome has a distinct pattern of grey matter (GM) atrophy, but despite FTD affecting individuals worldwide, these distributions of GM disease have rarely been validated in Latin America. METHODS: We report the imaging characteristics of 19 bvFTD, 11 naPPA, and 6 svPPA patients diagnosed using international consensus criteria at the Institute on Aging, Pontificia Universidad Javeriana in Colombia. Images were compared to those of 31 healthy controls recruited at the center. All subjects completed a high resolution (1mm isotropic) T1-weighted MRI scan. All MRI vo

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OBJECTIVE: To validate the neuroanatomical distribution of disease in clinical syndromes associated with frontotemporal degeneration (FTD) in Colombia. BACKGROUND: FTD is a clinically heterogeneous disorder that includes a behavioral variant (bvFTD) and two variants of primary progressive aphasia (PPA) characterized by non-fluent agrammatic speech (naPPA) and semantic deficits (svPPA). It is well established that each clinical syndrome has a distinct pattern of grey matter (GM) atrophy, but despite FTD affecting individuals worldwide, these distributions of GM disease have rarely been validated in Latin America. METHODS: We report the imaging characteristics of 19 bvFTD, 11 naPPA, and 6 svPPA patients diagnosed using international consensus criteria at the Institute on Aging, Pontificia Universidad Javeriana in Colombia. Images were compared to those of 31 healthy controls recruited at the center. All subjects completed a high resolution (1mm isotropic) T1-weighted MRI scan. All MRI vo

Keywords

Grey matterCohortMedicineFrontotemporal dementiaDegeneration (medical)Frontotemporal lobar degenerationDiseaseDegenerative disease

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