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Open AccessArticle10.1016/s0021-9258(18)65548-6

EFFECT OF DIET ON THE ANTIMYCIN TITER OF MOUSE LIVER

Arnold E. Reif,R. R. Brown,Van R. Potter,E. C. Miller,James A. Miller-1954-07-01-Journal of Biological Chemistry
10

TL;DRAbstract

Potter and Reif (l-3) have reported a method for estimating the tissue level of a hydrogen transport component essential for the oxidation of the tricarboxylic acid cycle and for certain other oxidations.The method consists of measuring the quantity of a specific inhibitor, antimycin A, required to produce 50 per cent inhibition of the succinoxidase activity of a unit weight of tissue; this quantity is the "antimycin titer" of the tissue.Brown, Miller, and Miller (4) found that various dietary peroxides and hydrocarbons will stimulate the oxidative Ndemethylation of 3-methyl-4monomethylaminoazobenzene to 3-methyl-4-aminoazobenzene (3-methyl-AB) by fortified liver homogenates.The present paper shows that some of these dietary conditions also cause an increase in the antimycin titer of mouse liver.EXPERIMENTAL

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Potter and Reif (l-3) have reported a method for estimating the tissue level of a hydrogen transport component essential for the oxidation of the tricarboxylic acid cycle and for certain other oxidations.The method consists of measuring the quantity of a specific inhibitor, antimycin A, required to produce 50 per cent inhibition of the succinoxidase activity of a unit weight of tissue; this quantity is the "antimycin titer" of the tissue.Brown, Miller, and Miller (4) found that various dietary peroxides and hydrocarbons will stimulate the oxidative Ndemethylation of 3-methyl-4monomethylaminoazobenzene to 3-methyl-4-aminoazobenzene (3-methyl-AB) by fortified liver homogenates.The present paper shows that some of these dietary conditions also cause an increase in the antimycin titer of mouse liver.EXPERIMENTAL

Keywords

TiterAntimycin AChemistryBiologyBiochemistryVirologyMitochondrion

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