User Settings
Article10.1161/circ.116.suppl_16.ii_782

Abstract 3458: Dietary Arachidonic Acid, 5-Lipoxygenase and Myocardial Infarction

Hannia Campos,Baylin Ana,Janna Hartiala,Hooman Allayee-2007-10-16-Circulation
1

TL;DRAbstract

Five-lipoxygenase (5-LO), the rate-limiting enzyme in the biosynthesis of leukotrienes from arachidonic acid, has been associated with the development of atherosclerosis in mouse models, and a 5-LO promoter repeat polymorphism has been implicated in atherosclerosis in humans. To test the effect of the 5-LO polymorphism on risk of MI and whether dietary arachidonic acid modified the observed results, we studied 1,885 cases of myocardial infarction (MI) and 1,885 controls matched for age, sex, and area of residence, all living in Costa Rica. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95%CI). Dietary intake was assessed by a validated food frequency questionnaire. No case-control differences in the frequency of deletion (DD/WD) or addition (AA/WA) alleles were identified: DD/WD=28.7% and 29.7%; AA/WA=2.35% and 3.1%, respectively. However, a significant gene-diet interaction was found between the 5-LO polymorphism, arachidonic acid i

Chat with Paper

AI Agents for this Paper

Five-lipoxygenase (5-LO), the rate-limiting enzyme in the biosynthesis of leukotrienes from arachidonic acid, has been associated with the development of atherosclerosis in mouse models, and a 5-LO promoter repeat polymorphism has been implicated in atherosclerosis in humans. To test the effect of the 5-LO polymorphism on risk of MI and whether dietary arachidonic acid modified the observed results, we studied 1,885 cases of myocardial infarction (MI) and 1,885 controls matched for age, sex, and area of residence, all living in Costa Rica. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95%CI). Dietary intake was assessed by a validated food frequency questionnaire. No case-control differences in the frequency of deletion (DD/WD) or addition (AA/WA) alleles were identified: DD/WD=28.7% and 29.7%; AA/WA=2.35% and 3.1%, respectively. However, a significant gene-diet interaction was found between the 5-LO polymorphism, arachidonic acid i

Keywords

Arachidonic acidMedicineInternal medicineOdds ratioConfidence intervalAlleleEndocrinologyLipoxygenase

Chat

Click to start Chat