High-throughput DNA Sequencing Identifies Novel <i>CtIP (RBBP8)</i> Variants in Muscle-invasive Bladder Cancer Patients

TL;DRAbstract

We have demonstrated proof of principle for dual indexing on 160 samples on one MiSeq flow cell sequencing surface, and show that for the CtIP gene multiplexing of up to 720 samples would provide sufficient coverage to achieve >98% detection power for rare germline variation, reducing HTS costs substantially.

Chat with Paper

AI Agents for this Paper