Localisation of LRP1 in neurons and glia of the central nervous system

TL;DRAbstract

The low density lipoprotein receptor-related protein-1 (LRP1) receptor modulates neuronal survival, neurite outgrowth, regeneration and calcium signaling. Its effects are thought to be ligand and cell specific, but how LRP1 is able to differentiate between different signals to produce specific responses is unclear. The subcellular localisation of LRP1 in neurons and glia of the central nervous system (CNS) was investigated to gain insight into the receptor's role in specific cell types and during maturation. The role of LRP1 in calcium signaling and regeneration following injury was assessed using two of its ligands, metallothionein (MT) and emtinB. Expression and localisation of LRP1 in vivo and in vitro was determined using western blot analysis and immunochemistry. LRP1 was expressed in neurons and glia of post-natal day 2 (P2), P7 and adult rat brains. Greater immunoreactivity was demonstrated in P2 compared to adult brain, mainly due to increased expression in neurons and oligoden

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